|
KMID : 0364020160490040242
|
|
Korean Journal of Thoracic and Cardiovascular Surgery
2016 Volume.49 No. 4 p.242 ~ p.249
|
|
|
Twenty-Year Experience of Heart Transplantation: Early and Long-Term Results
|
|
Lee Jae-Hong
Yeom Sang-Yoon
Hwang Ho-Young
Choi Jae-Woong
Cho Hyun-Jai
Lee Hae-Young
Huh Jae-Hak
Kim Ki-Bong
|
|
|
Abstract
|
|
|
Background: We evaluated early and long-term results after heart transplantation (HTPL).
Methods: One hundred five consecutive patients (male:female=80:25) who underwent HTPL between 1994 and 2013 were enrolled. Based on the changes in immunosuppressive regimen, the study patients were divided into two groups. Early and long-term clinical outcomes were evaluated and compared between the patients who underwent HTPL before (group E, n=41) and after July 2009 (group L, n=64). The group L patients were older (p＜0.001), had higher incidence of hypertension (p=0.001) and chronic kidney disease (p＜0.001), and more frequently needed preoperative mechanical ventilation (p=0.027) and mechanical circulatory support (p=0.014) than the group E patients.
Results: Overall operative mortality was 3.8%, and postoperative morbidities included acute kidney injury (n=31), respiratory complications (n=16), reoperation for bleeding (n=15) and wound complications (n=10). There were no significant differences in early results except acute kidney injury between group E and group L patients. Overall survival rates at 1, 5, and 10 years were 83.8%, 67.7%, and 54.9%, respectively, with no significant difference between the two patient groups. Rejection-free rates at 1 and 5 years were 63.0% and 59.7%, respectively; rates were significantly higher in group L than in group E (p＜0.001).
Conclusion: Despite increased preoperative comorbidities, group L patients showed similar early and long-term outcomes and significantly higher rejection-free rates when compared with group E patients.
|
|
|
KEYWORD
|
|
|
Transplantation, Heart, Outcome assessment
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|